B Braun L7510 - 5% Dextrose in Lactated Ringer's Injection, 1000 mL, 12/CS

B Braun L7510 - 5% Dextrose in Lactated Ringer's Injection, 1000 mL, 12/CS

B Braun L7510 Dextrose in Lactated Ringer's Injection

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Lactated Ringer's Injection USP is sterile, nonpyrogenic and contains no bacteriostatic or antimicrobial agents. This product is intended for intravenous administration in a single dose container. This solution is indicated for use in adults and pediatric patients as a source of electrolytes and water for hydration.

Not manufactured with natural rubber latex, PVC or DEHP.

Specific Gravity:1.023

B Braun L7510 Clinical Pharmacology

5% Dextrose in Lactated Ringer's Injection provides electrolytes and calories, and is a source of water for hydration. It is capable of inducing diuresis depending on the clinical condition of the patient. This solution also contains lactate which produces a metabolic alkalinizing effect.

Sodium, the major cation of the extracellular fluid, functions primarily in the control of water distribution, fluid balance and osmotic pressure of body fluids. Sodium is also associated with chloride and bicarbonate in the regulation of the acid-base equilibrium of body fluid. Potassium, the principal cation of intracellular fluid, participates in carbohydrate utilization and protein synthesis, and is critical in the regulation of nerve conduction and muscle contraction, particularly in the heart.

Chloride, the major extracellular anion, closely follows the metabolism of sodium, and changes in the acid-base balance of the body are reflected by changes in the chloride concentration. Calcium, an important cation, provides the framework of bones and teeth in the form of calcium phosphate and calcium carbonate. In the ionized form, calcium is essential for the functional mechanism of the clotting of blood, normal cardiac function, and regulation of neuromuscular irritability.

Sodium lactate is a racemic salt containing both the levo form, which is oxidized by the liver to bicarbonate, and the dextro form, which is converted to glycogen. Lactate is slowly metabolized to carbon dioxide and water, accepting one hydrogen ion and resulting in the formation of bicarbonate for the lactate consumed. These reactions depend on oxidative cellular activity.

Dextrose provides a source of calories. Dextrose is readily metabolized, may decrease losses of body protein and nitrogen, promotes glycogen deposition and decreases or prevents ketosis if sufficient doses are provided.

Indications and Usage of B Braun L7510

This solution is indicated for use in adults and pediatric patients as a source of electrolytes, calories and water for hydration.

B Braun L7510 Dextrose in Lactated Ringer's Injection Contraindications

The use of 5% Dextrose in Lactated Ringers Injection is contraindicated in neonates (28 days of age or younger) receiving concomitant treatment with ceftriaxone, even if separate infusion lines are used, due to the risk of fatal ceftriaxone-calcium salt precipitation in the neonates bloodstream [see Warnings, Drug Interactions, Pediatric Use].

This solution is contraindicated where the administration of sodium, potassium, calcium, chloride or lactate could be clinically detrimental.

Lactate administration is contraindicated in severe metabolic acidosis or alkalosis, and in severe liver disease or anoxic states which affect lactate metabolism.

Solutions containing dextrose may be contraindicated in patients with hypersensitivity to corn products

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